منابع مشابه
Neurotrophic Factors: Neurotrophin autocrine loops
Developing neurons depend on neurotrophins supplied by the tissues they innervate. Before and after this period of target-dependent survival, brain-derived neurotrophic factor also has autocrine actions on some neurons.
متن کاملReal-time quantitative measurement of autocrine ligand binding indicates that autocrine loops are spatially localized.
Autocrine ligands are important regulators of many normal tissues and have been implicated in a number of disease states, including cancer. However, because by definition autocrine ligands are synthesized, secreted, and bound to cell receptors within an intrinsically self-contained "loop," standard pharmacological approaches cannot be used to investigate relationships between ligand/receptor bi...
متن کاملThree autocrine feedback loops determine HIF1α expression in chronic hypoxia
Hypoxia occurs in cancer, prolonged exercise, and long-term ischemia with durations of several hours or more, and the hypoxia-inducible factor 1 (HIF1) pathway response to these conditions differs from responses to transient hypoxia. We used computational modeling, validated by experiments, to gain a quantitative, temporal understanding of the mechanisms driving HIF1 response. To test the hypot...
متن کاملAutocrine loops with positive feedback enable context-dependent cell signaling.
We describe a mechanism for context-dependent cell signaling mediated by autocrine loops with positive feedback. We demonstrate that the composition of the extracellular medium can critically influence the intracellular signaling dynamics induced by extracellular stimuli. Specifically, in the epidermal growth factor receptor (EGFR) system, amplitude and duration of mitogen-activated protein kin...
متن کاملGrowth factor/growth factor receptor loops in autocrine growth regulation of human prostate cancer DU145 cells.
Autocrine growth factors produced by epithelial cells mediate the development and proliferation of neoplastic human prostate tissue. Various approaches have been used to down-regulate neoplastic growth of prostate cancer using natural flavonoids, soluble receptors, pseudo-ligands, monoclonal antibodies and tyrosine kinase inhibitors (tyrphostins). Selected growth factor/growth factor receptor l...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2001
ISSN: 1465-6906
DOI: 10.1186/gb-spotlight-20011101-01